The new members of BioCare Chile

BioCare® has been developing a range of nutritional supplements of the highest quality and availability for more than thirty years, based on strict quality and purity standards. Always seeking to be at the forefront to bring each of you what you need for every minute of life.

That's why today we bring you three new products to accompany you and support you to have the best possible health.

Magnesium taurate

It is a form of magnesium that is chelated with an amino acid called taurine. It is one of the most highly absorbed forms that is mainly used for the treatment of stress, anxiety, insomnia, in addition to being a liver and biliary support and can support eye health.

Taurine is a sulfur amino acid that promotes the production of the neurotransmitter GABA, which is related to calm, helping to improve stress and anxiety. Widely used for its role in managing stress, anxiety and insomnia. In addition to being a support for liver and biliary, cardiovascular, circulatory health, cholesterol balance and arrhythmias.

At the digestion level , taurine is used in the conjugation of bile salts, so it helps the emulsification of fats, improves fat absorption and excretion of bile salts. On the other hand, its role in cardiovascular health is due to the stimulation by taurine of an enzyme called 7-alpha cholesterol dehydroxylase, which is responsible for converting cholesterol into bile salts, causing a decrease in LDL cholesterol . Additionally, some studies have shown a decrease in blood pressure with taurine supplementation.

Why Biocare and not another? : At BioCare we make sure to use the least amount of ingredients and excipients possible, being not only high potency and effectiveness but also clean and healthy.

Vitamin D3 spray

It is a high-potency vitamin with a pleasant lemon flavor that provides 1000 IU per spray, it is also vegan and suitable for pregnancy and breastfeeding.

The levels of vitamin D deficiency in Chile are very high, even in women. According to the National Health Survey of the year 2016-2017, 84% of women had some degree of deficiency, in addition to only 13.4% of older adults presented adequate levels. Unfortunately, due to the latitude in which we live, the use of sunscreen and clothing makes it increasingly difficult for us to maintain adequate levels of this vitamin.

Vitamin D3 participates in bone health processes, autoimmune diseases, allergies, skin problems such as eczema and psoriasis, digestive problems such as irritable bowel syndrome and bile problems. Other functions are linked to the regulation of cell replication in carcinogenic processes, cholesterol metabolism, insulin regulation, and neurotransmitter production. among other.

This is why we increasingly realize the importance of maintaining adequate levels of this vitamin.

Vitamin D deficiency has been associated with various health problems such as: mental health problems, cardiovascular disease, osteoporosis, infertility and sex hormone dysfunction, as well as allergies and autoimmune conditions.

The population at greatest risk of deficiency are pregnant women and children, older adults, people with dark skin or those who are overweight/obese.

calcium citrate

Our version of calcium citrate is the chemical form with the highest bioavailability, very important for bone and muscle health. Provides 300mg of elemental calcium per serving.

Specially designed for people with bone health problems such as osteopenia, osteoporosis and osteomalacia, as well as muscle support, cramps and exercise, as well as cardiovascular support.

On the other hand, calcium citrate, in addition to helping maintain bone and dental health, supports a wide range of functions in the body, including neurotransmission, blood coagulation, muscle and cardiac muscle contraction, and cell division.

Additionally, calcium can be especially useful during pregnancy and breastfeeding to stimulate the growth and development of the baby, in addition to preventing deficiencies in the mother. Along with this, calcium supplementation can help reduce the risk of preeclampsia in the mother.

Our calcium citrate is suitable for vegetarians, vegans and those who are pregnant and breastfeeding, and it can also be used from 6 months of age by opening the capsule.

References:

1. Swaminathan R. Magnesium metabolism and its disorders. Clin Biochem Rev 2003;24(2):47-66. Accessed October 27, 2020. http://www.ncbi.nlm.nih.gov/pubmed/18568054
2. Yang L, Arora K, Beard WA, Wilson SH, Schlick T. Critical role of magnesium ions in DNA polymerase β's closing and active site assembly. J Am Che Soc. 2004;126(27):8441-8453. doi:10.1021/ja049412o
3. Ross AC, Caballero BH, Cousins ​​RJ, Tucker KL, Ziegler TR. Modern Nutrition in Health and Disease: Eleventh Edition. Wolters Kluwer Health Adis (ESP); 2012. Accessed October 27, 2020. https://jhu.pure.elsevier.com/en/publications/modern-nutrition-in-health-and-disease-eleventh-edition
4. Stebbing JB, Turner M 0, Franz KB. Magnesium-Bulletin 2/1982 Reactive Hypoglycemia and Magnesium~:-).
5. Hruby A, McKeown NM, Song Y, Djoussé L. Dietary magnesium and genetic interactions in diabetes and related risk factors: A brief overview of current knowledge. Nutrients. 2013;5(12):4990-5011. doi:10.3390/nu5124990
6. Hruby A, Ngwa JS, Renström F, et al. Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE consortium studies1-4. J Nutr. 2013;143(3):345-353. doi:10.3945/jn.112.172049
7. Dibaba DT, Xun P, Song Y, Rosanoff A, Shechter M, He K. The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: A meta-analysis of randomized controlled trials. Am J Clin Nutr. 2017;106(3):921-929. doi:10.3945/ajcn.117.155291
8. Belfort MA, Anthony J, Saade GR, Allen JC. A Comparison of Magnesium Sulfate and Nimodipine for the Prevention f Eclampsia. N Engl J Med. 2003;348(4):304-311. doi:10.1056/NEJMoa021180
9. Zarean E, Tarjan A. Effect of Magnesium Supplement on Pregnancy Outcomes: A Randomized Control Trial. Adv Biomed Res. 2017;6(1):109. doi:10.4103/2277-9175.213879
10. McDonald SD, Lutsiv O, Dzaja N, Duley L. A systematic review of maternal and infant outcomes following magnesium sulfate for pre-eclampsia/eclampsia in real-world use. Int J Gynecol Obstet. 2012;118(2):90-96. doi:10.1016/j.ijgo.2012.01.028
11. Erickson KL, Medina EA, Hubbard NE. Micronutrients and innate immunity. In: Journal of Infectious Diseases. Vol 182. University of Chicago Press; 2000. doi:10.1086/315922
12. Held K, Antonijevic IA, Künzel H, et al. Oral Mg2+ supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry. 2002;35(4):135-143. doi:10.1055/s-2002-33195
13. Reid IR, Bolland MJ. Role of vitamin D deficiency in cardiovascular disease. doi:10.1136/heartjnl-2011-301356
14. Krishnan A V., Feldman D. Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D.
15. Annu Rev Pharmacol Toxicol. 2011;51:311-336. doi:10.1146/annurev-pharmtox-010510-100611
16. Fleet JC, Desmet M, Johnson R, Li Y. Vitamin D and cancer: A review of molecular mechanisms. Biochemical Journal. 2012;441(1):61-76. doi:10.1042/BJ20110744
17. Blutt SE, Mcdonnell TJ, Polek TC, Weigel NL. Calcitriol-induced apoptosis in LNCaP cells is blocked by overexpression of Bcl-2. Endocrinology. 2000;141(1):10-17. doi:10.1210/endo.141.1.7289
18. Deeb KK, Trump DL, Johnson CS. Vitamin D signaling pathways in cancer: Potential for anticancer therapeutics. Nat Rev Cancer. 2007;7(9):684-700. doi:10.1038/nrc21966. Zhang T, De Carolis C, Man GCW, Wang CC. The link between immunity, autoimmunity and endometriosis: a literature update. Autoimmun Rev 2018;17(10):945-955. doi:10.1016/j.autrev.2018.03.017
19. Gagnon C, Lu ZX, Magliano DJ, et al. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: Results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). Journal of Clinical Endocrinology and Metabolism. 2012;97(6):1953-1961. doi:10.1210/jc.2011-3187
20. Kong J, Zhang Z, Musch MW, et al. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol. 2007;294(1). doi:10.1152/ajpgi.00398.2007
21. Smith SA, Travers RJ, Morrissey JH. How it all starts: initiation of the clotting cascade. doi:10.3109/10409238.2015.1050550 2. SM B, GD G, AS, AM H, IR R. Acute effects of calcium supplements on blood pressure and blood coagulation: secondary analysis of a randomized controlled trial in post-menopausal women. The British journal of nutrition. 2015;114(11):1868-1874. doi:10.1017/S0007114515003694
22. Hofmeyr GJ, Lawrie TA, Atallah ÁN, Torloni MR, Group CP, Childbirth. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. The Cochrane Database of Systematic Reviews. 2018;2018(10). doi:10.1002/14651858.CD001059.PUB5
23. Davies JH, Evans AJ. Bone mass acquisition in healthy children. Arch Dis Child. 2005;90:373-378. doi:10.1136/adc.2004.053553 AM K, KM P, BB, et al. Comparison of the effects of calcium loading with calcium citrate or calcium carbonate on bone turnover in postmenopausal women. Osteoporosis international: a journal established as a result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2004;15(4):290-294. doi:10.1007/S00198-003-1567-0
24. C G. Calcium and vitamin D nutrition and bone disease of the elderly. Public health nutrition. 2001;4(2B):362-369. doi:10.1079/PHN2001140 IR R, SM B, MJ B. Calcium supplements: benefits and risks. Journal of internal medicine. 2015;278(4):354-368. doi:10.1111/JOIM.1239 RC, FP, ES, SR, G M. Appropriate nutrient supplementation in celiac disease. Annals of medicine. 2013;45(8):522- 531. doi:10.3109/07853890.2013.849383 9. DR, IM, CR, et al. The progression of coronary artery calcification in predialysis patients on calcium carbonate or sevelamer. Kidney international. 2007;72(10):1255-1261. doi:10.1038/SJ.KI.5002518 10. MJ B, AA, JA B, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ (Clinical research ed). 2010;341(7767):289. doi:10.1136/BMJ.C3691
25. 11. ML P, ML, AA L. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleveland Clinic journal of medicine. 2001;68(11):945-951. doi:10.3949/CCJM.68.11.945 12. JF B, RM, PW, et al. The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis. Journal of the American Academy of Dermatology. 1997;37(6):929-934. doi:10.1016/S0190- 9622(97)70067-7 CR S. Calcium carbonate and reduction of levothyroxine efficacy. JAMA. 1998;279(10):750-b-750. doi:10.1001/JAMA.279.10.750-B
26. Murray JJ, Healy MD. Drug-mineral interactions: A new responsibility for the hospital dietitian. Journal of the American Dietetic Association. 1991;91(1). doi:10.1016/s0002-8223(21)01064-6 MW P, PP, AA, OB, H L. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrobial agents and chemotherapy. 2003;47(7):2158-2160. doi:10.1128/AAC.47.7.2158-2160.2003
27. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Seminars in Nephrology. 1999;19(6):551-556. https://pubmed.ncbi.nlm.nih.gov/10598542/Hyperparathyroidism, hypercalcemia and difficult laryngoscopy: a retrospective review - PubMed. Accessed September 7, 2021. https://pubmed.ncbi.nlm.nih.gov/23265028/ SE C, PH N, PV, L M. Familial hypocalciuric hypercalcaemia: a review. Current opinion in endocrinology, diabetes, and obesity. 2011;18(6):359-370. doi:10.1097/MED.0B013E32834C3C7CBS P, LA M. Nutritional aspects of the prevention and treatment of osteoporosis. Brazilian archives of endocrinology and metabolism. 2010;54(2):179-185. doi:10.1590/S0004-27302010000200014. B L. Calcium and iron absorption--mechanisms and public health relevance. International journal for vitamin and nutrition research Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung Journal international de vitaminologie et de nutrition. 2010;80(4-5):293-299. doi:10.1024/0300-9831/A000036
28. RJ W, JJ Z. High dietary calcium intakes reduce zinc absorption and balance in humans. The American journal of clinical nutrition. 1997;65(6):1803-1809. doi:10.1093/AJCN/65.6.1803MJ B, AG, AA, GD G, IR R. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ (Clinical research ed). 2011;342(7804). doi:10.1136/BMJ.D2040